Our services
in the fields of Biopharmaceuticals

Discover CellXplore ™

CellXplore ™ is the first in-flow cellular deformation analyzer, a unique service developed by CelliXiO to explore, predict, and optimize the effects of fluidic shear stress on cells. Designed for biopharmaceutical companies and equipment manufacturers, CellXplore ™ enables the development of safer, more efficient bioprocesses—For example by placing in vitro cellular behavior within your equipment and process.

Increase Bioproduction Yields for USP

Reduce Production Costs for DSP

Ensure Process Robustness & Scability

Reproduction of Shear Stress on cells, analysis

A Closer Look at the CellXplore ™ Workflow

CellXplore ™ follows a powerful three-phase process into microfluidic cheap, combining simulation, biological experimentation, and AI-driven analysis. In the first phase, we create a digital model of your equipment using CAD and CFD simulations, generating a detailed shear stress map under your specific flow conditions. In the second phase, your cells are exposed to these stress conditions into the microfluidic cheap—without any fluorescent markers—and each cell is classified as viable, apoptotic, or necrotic, creating a precise viability map inside your device. In the final phase, you receive actionable insights to optimize your setup. To sum up, thanks to a “Build – Test – Repeat” approach, CellXplore allows you to test multiple flow conditions in a single experiment, drastically reducing development time and improving process precision.

The CellXplore™ service pipeline has been designed to mirror real bioprocess conditions while delivering highly valuable data.
We begin with fluidic modeling of your equipment using CFD tools, allowing us to simulate flow behavior and predict high-shear zones.
Next, we prepare your cells of interest—typically between 50,000 to 1 million. After thawing, a sample of 2,000 to 10,000 cells is used per run, enabling efficient screening without excessive resource use. Your cells are then exposed to real flow conditions in a controlled setup.
Moreover, an integrated AI engine processes this image data in real time, classifying each cell by its physiological state and generating a report on viability distribution within the flow system. Finally, we assist you in optimizing your equipment or process, adjusting flow velocity, viscosity, or even the geometry of your design based on predictive insights—ensuring the best possible cell–equipment compatibility.

The 3 key phases of the process

Equipment
modeling

CAD files

CFD simulation

Theoretical Shear Stress Mapping

Viability
prediction

Cell-by-cell classification

Viable / Necrotic / Apoptotic

Viability mapping within
the equipment

Equipment Optimization

Build – Test – Repeat

All conditions tested
in a single run

Ready to explore the full potential of CellXplore™?

Added Value for Biopharma & Equipment Manufacturers

Our service CellXplore empowers both Biopharma and Equipment Manufacturers to design with biology in mind—placing cellular behavior at the heart of process development. As a result, by uncovering how cells respond to mechanical stress in real conditions, CellXplore™ offers a unique ability to increase bioproduction yields, reduce production costs, and ensure robustness and traceability across the entire process lifecycle.

Measure mechanical resistance of cells in suspension

Analyze cell viability, apoptosis, and necrosis without labeling

Support sustainability goals by reducing waste, reagents, and emissions

Rationalize scale-up and process optimization, removing trial-and-error steps

How does it work?

What you provide

To initiate a CellXplore™ analysis, you simply need to provide:

A batch of frozen cells (from 50,000 to 1 million)

A CAD or CFD file of your equipment

What you receive

In just a few days, you’ll gain access to:

Mechanical resistance curves for your cells under shear stress, showing the

Proportions of viable, apoptotic, and necrotic cells

A predictive viability map within your equipment, under your specific flow conditions

Your advantages

A fast, efficient, and fully remote service:

Fast turnaround time: results delivered within 1 to 2 weeks

No on-site intervention required—everything is performed off-site, using your digital and biological inputs

Model, Predict, Optimize

Key Benefits of CellXplore ™

With CellXplore™, your team gains access to deep, actionable biological data within your process design.
In short, by identifying which cells thrive—or fail—under shear conditions, you can optimize cell selection and handling protocols to increase production yields. Furthermore, this approach ensures that only the most resistant and viable cells are carried forward into critical stages of development and manufacturing.
In parallel, CellXplore ™ helps reduce process-related cell losses, enabling more consistent downstream recovery and reducing overall production costs. Consequently, the result is a leaner, smarter, and more sustainable bioprocess.

Access deep, actionable biological data to inform process design

Identify and select the most shear-resistant, viable cells

Optimize handling protocols to increase production yields

Reduce cell losses and improve downstream consistency

Lower production costs and enhance bioprocess sustainability

Get Started Today

Reach out to learn more about our innovative services.

Our servicesin the fields of Biopharmaceuticals